Speaker Date Topic
Diane Worthey, Musician Aug 22, 2018 12:00 PM
Antonia Brico's Journey of Perseverance.

         From an unhappy childhood, Antonia Brico forged a path of her own to become the first woman to graduate from the prestigious Master School of Conducting in Berlin in 1930. Antonia struggled her entire life to find her rightful place on the podium, as women were not appointed to leadership roles in the field of classical music.
         Antonia never enjoyed the career of her male counterparts, yet she broke barriers for women. Today there are many women conductors of major symphony orchestras, who stand on Antonia’s shoulders.

Dr. Michael Skinner, Ctr. for Reproductive Biology Aug 29, 2018 12:00 PM
Epigenetics and the Ancestral Ghosts in Your DNA.

          Transgenerational effects of environmental toxicants, nutrition or stress significantly amplify the biological impacts and health hazards of these exposures. One of the most sensitive periods to exposure is during fetal gonadal sex determination when the germ line is undergoing epigenetic programming and DNA re-methylation occurs. Previous studies have shown that toxicants can cause an increase in adult onset disease such as infertility, prostate, ovary and kidney disease, cancers and obesity. Interestingly, this effect is transgenerational (F1, F2, F3 and F4 generations) and hypothesized to be due to a permanent (imprinted) altered epimutation of the germ-line.
          The transgenerational epigenetic mechanism appears to involve the actions of an environmental compound at the time of sex determination to permanently alter the epigenetic (e.g. DNA methylation) programming of the germ line that then alters the transcriptomes of developing organs to induce disease susceptibility and development transgenerationally. In addition to DNA methylation, alterations in sperm ncRNAs and histone retention have also been observed. A variety of different environmental compounds have been shown to induce this epigenetic transgenerational inheritance of disease including: fungicide vinclozolin, plastics BPA and phthalates, pesticides, DDT, dioxin and hydrocarbons. Interestingly, exposure specific epigenetic alterations were observed between the specific toxicants.
          Similar observations have been observed in other species such as alligators, Darwin’s finches and New Zealand mud snails. The suggestion that environmental factors can reprogram the germ line to induce epigenetic transgenerational inheritance of disease and phenotypic variation is a new paradigm in disease etiology that is also relevant to other areas of biology such as evolution. 

 

Emily McBride Sep 05, 2018 12:00 PM
RYLA (Rotary Youth Leadership Awards)
Alison Weigley Sep 12, 2018 12:00 PM
Classification Speech

We look forward to hearing our own Alison tell us about herself!

Jennifer Wallace, Executive Director Sep 26, 2018 12:00 PM
Habitat for Humanity Organizational Update